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Chapter 8 Vitamin D

By Food and Agriculture Organization of the United Nations

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Book Id: WPLBN0000142394
Format Type: PDF eBook
File Size: 0.3 MB
Reproduction Date: Available via World Wide Web.
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Title: Chapter 8 Vitamin D  
Author: Food and Agriculture Organization of the United Nations
Language: English
Subject: United Nations., Food and Agriculture Organization of the United Nations. FAO agriculture series, Agriculture
Collections: United Nations Food and Agriculture Organization Collection
Publication Date:
Publisher: Food and Agriculture Organization of the United Nations; Digitizer: Fao


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Agriculture Organization Of The United Nations, F. A. (n.d.). Chapter 8 Vitamin D. Retrieved from

Nutrition Reference Publication

Electronic reproduction.

Summary: of the role of vitamin D in human metabolic processes Vitamin D is required to maintain normal blood levels of calcium and phosphate, that are in turn needed for the normal mineralisation of bone, muscle contraction, nerve conduction, and general cellular function in all cells of the body. Vitamin D achieves this after its conversion to the active form 1,25-dihydroxyvitamin D [1,25-(OH)2D], or calcitriol. This active form regulates the transcription of a number of vitamin D?dependent genes coding for calcium-transporting proteins and bone matrix proteins. Vitamin D also modulates the transcription of cell cycle proteins, that decrease cell proliferation and increase cell differentiation of a number of specialised cells of the body (e.g. ... osteoclastic precursors, enterocytes, keratinocytes, etc.). This property may explain the actions of vitamin D in bone resorption, intestinal calcium transport, and skin. Vitamin D also possesses immuno-modulatory properties that may alter responses to infections in vivo. The cell differentiating and immuno-modulatory properties underlie the reason why vitamin D derivatives are now used successfully in the treatment of psoriasis and other skin disorders. Clinical assays measure 1,25-(OH)2D2 and 1,25-(OH)2D3, collectively called 1,25-(OH)2D. Similarly, calcidiol is measured as 25-OH-D but it is a mixture of 25-OH-D2 and 25-OH-D3. For the purposes of this document, 1,25-(OH)2D and 25-OH-D will be used to refer to calcitriol and calcidiol, respectively.


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