Toxicological Review of Methyl Isobutyl Ketone

By Anitole, Katherine, Ph. D.

Description
Excerpt: This document and summary information on IRIS have received peer review by both EPA scientists and independent scientists external to EPA. Subsequent to external review and incorporation of comments, this assessment has undergone an Agency-wide review process whereby the IRIS Program Director has achieved a consensus approval among the Office of Research and Development; Office of Air and Radiation; Office of Prevention, Pesticides, and Toxic Substances; Office of Solid Waste and Emergency Response; Office of Water; Office of Policy, Economics, and Innovation; Office of Children’s Health Protection; Office of Environmental Information; and the Regional Offices.

Table of Contents
CONTENTS—TOXICOLOGICAL REVIEW for METHYL ISOBUTYL KETONE (CAS No. 108-10-1) FOREWORD .................................................................v AUTHORS, CONTRIBUTORS, AND REVIEWERS ................................ vi 1. INTRODUCTION ..........................................................1 2. CHEMICAL AND PHYSICAL INFORMATION RELEVANT TO ASSESSMENTS .....2 3. TOXICOKINETICS RELEVANT TO ASSESSMENTS ............................4 3.1. ABSORPTION .....................................................4 3.1.1. Gastrointestinal Absorption ....................................4 3.1.2. Respiratory Tract Absorption ...................................4 3.1.3. Dermal Absorption ...........................................4 3.2. DISTRIBUTION ....................................................4 3.3. METABOLISM .....................................................5 3.4. ELIMINATION AND EXCRETION ....................................6 3.5. PHYSIOLOGICALLY-BASED PHARMACOKINETIC (PBPK) MODELS .....6 4. HAZARD IDENTIFICATION.................................................6 4.1. STUDIES IN HUMANS—EPIDEMIOLOGY, CASE REPORTS, CLINICAL CONTROLS .....................................................6 4.1.1. Oral Exposure ...............................................7 4.1.2. Inhalation Exposure ..........................................7 4.2. PRECHRONIC AND CHRONIC STUDIES AND CANCER BIOASSAYS IN ANIMALS .......................................................9 4.2.1. Oral Exposure ...............................................9 4.2.2. Inhalation Exposure .........................................11 4.3. REPRODUCTIVE/DEVELOPMENTAL STUDIES .......................13 4.4. OTHER STUDIES..................................................16 4.4.1. Neurotoxicity ..............................................16 4.4.2 Genotoxicity................................................18 4.4.3. Potentiation and Other Interaction Studies ........................18 4.4.4. Mode of Action Studies ......................................20 4.5. SYNTHESIS AND EVALUATION OF MAJOR NONCANCER EFFECTS AND MODE OF ACTION ..............................................21 4.5.1. Oral Exposure ..............................................21 4.5.2. Inhalation Exposure .........................................25 4.6. WEIGHT-OF-EVIDENCE EVALUATION AND CANCER CHARACTERIZATION ...........................................36 4.7. SUSCEPTIBLE POPULATIONS AND LIFESTAGES .....................36

Book Id: WPLBN0000061420
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Reproduction Date: 2007
Full Text

Title:

Toxicological Review of Methyl Isobutyl Ketone

Author:

Anitole, Katherine, Ph. D.

Volume:

Language:

English

Subject:

Ecology, Natural resource issues, Environemtal protection

Collection:

Environmental Awareness Library Collection

Subcollection:

Historic
Publication Date:

Publisher:

U.S. Environmental Protection Agency

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