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Barry Marshall

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Barry Marshall

Barry Marshall
Barry Marshall in 2008
Born Barry James Marshall
(1951-09-30) 30 September 1951 [1]
Kalgoorlie, Western Australia
Citizenship Australian
Nationality Australian
Fields
Institutions
Alma mater University of Western Australia (MB BS)[1]
Known for Helicobacter pylori
Notable awards
Spouse Adrienne Joyce Feldman (m. 1972)[1]
Children 1 son, 3 daughters[1]
Website
.au.com.hpyloriwww

Barry James Marshall, AC,[1] FRACP, FRS,[3] FAA, DSc (born 30 September 1951) is an Australian physician, Nobel Prize laureate in Physiology or Medicine (the only laureate born in Western Australia), and Professor of Clinical Microbiology at the University of Western Australia. Marshall and Robin Warren showed that the bacterium Helicobacter pylori (H. pylori) is the cause of most peptic ulcers, reversing decades of medical doctrine holding that ulcers were caused by stress, spicy foods, and too much acid. This discovery has allowed for a breakthrough in understanding a causative link between Helicobacter pylori infection and stomach cancer.[4][5][6]

Contents

  • Education and early life 1
  • Life and research 2
  • Awards and honours 3
  • References 4
  • External links 5

Education and early life

Marshall was born in Kalgoorlie, Western Australia and lived in Kalgoorlie and Carnarvon until moving to Perth at the age of eight. His father held various jobs, and his mother was a nurse. He is the eldest of four siblings. He attended Newman College and the University of Western Australia, where he received a Bachelor of Medicine, Bachelor of Surgery (MBBS) in 1974.[1] He married his wife Adrienne in 1972 and has four children.[7][8][9]

Life and research

In 1979, Marshall was appointed as a Registrar in Medicine at the Royal Perth Hospital. He met Robin Warren, a pathologist interested in gastritis, during internal medicine fellowship training at Royal Perth Hospital in 1981. Together, the pair studied the presence of spiral bacteria in association with gastritis. In 1982, they performed the initial culture of H. pylori and developed their hypothesis related to the bacterial cause of peptic ulcer and gastric cancer.[7] It has been claimed that the H. pylori theory was ridiculed by the establishment scientists and doctors, who did not believe that any bacteria could live in the acidic environment of the stomach. Marshall has been quoted as saying in 1998 that "(e)veryone was against me, but I knew I was right."[10] On the other hand, it has also been argued that medical researchers showed a proper degree of scientific scepticism until the H. pylori hypothesis could be supported by evidence.[11]

After failed attempts to infect piglets in 1984, Marshall, after having a baseline Koch's postulates for H. pylori and gastritis, but not for peptic ulcer. This experiment was published in 1985 in the Medical Journal of Australia[13] and is among the most cited articles from the journal.[14]

After his work at Fremantle Hospital, Marshall did research at Royal Perth Hospital (1985–86) and at the University of Virginia, USA (1986–Present), before returning to Australia while remaining on the faculty of the University of Virginia.[2] He held a Burnet Fellowship at the University of Western Australia (UWA) from 1998–2003.[15] Marshall continues research related to H. pylori and runs the H. pylori Research Laboratory at UWA.[16]

In 2007, Marshall accepted a part-time appointment at the Pennsylvania State University.[17]

Awards and honours

In 2005, the Karolinska Institute in Stockholm awarded the Nobel Prize in Physiology or Medicine to Marshall and Robin Warren, his long-time collaborator, "for their discovery of the bacterium Helicobacter pylori and its role in gastritis and peptic ulcer disease".[18]

Marshall also received the Warren Alpert Prize in 1994; the Australian Medical Association Award and the Albert Lasker Award for Clinical Medical Research in 1995; the Gairdner Foundation International Award in 1996; the Paul Ehrlich and Ludwig Darmstaedter Prize in 1997; the Dr A.H. Heineken Prize for Medicine, the Florey Medal, and the Buchanan Medal of the Royal Society in 1998 and was elected a Fellow of the Royal Society (FRS) in 1999. His certificate of election to the Royal Society reads:

Marshall was awarded the Benjamin Franklin Medal for Life Sciences in 1999; the Keio Medical Science Prize in 2002; and the Australian Centenary Medal in 2003.[19] Marshall was appointed a Companion of the Order of Australia in 2007.[20] He was awarded an honorary Doctor of Science degree by the University of Oxford in 2009.[21]

References

  1. ^ a b c d e f MARSHALL, Prof. Barry James.   (subscription required)
  2. ^ a b "U.Va. Top News Daily". Virginia.edu. 4 October 2005. Archived from the original on 4 April 2010. Retrieved 2 March 2010. 
  3. ^ a b c "Certificate of Election EC/1999/24: Barry James Marshall". London:  
  4. ^ Marshall BJ, Warren JR (June 1983). "Unidentified curved bacilli on gastric epithelium in active chronic gastritis". Lancet 321 (8336): 1273–5.  
  5. ^ Marshall BJ, Warren JR (June 1984). "Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration". Lancet 323 (8390): 1311–5.  
  6. ^ Sweet, Melissa (2 August 1997). "Smug as a bug".  
  7. ^ a b Barry, Marshall (2005). "Autobiography".  
  8. ^ In 1972 he was also a state yo-yo champion.
  9. ^ "Sydney Morning Herald Features Barry Marshall Helicobacter pylori". Vianet.net.au. 2 August 1997. Retrieved 2 March 2010. 
  10. ^ "Barry Marshall Interview, H. Pylori and the Making of a Myth".  
  11. ^ Atwood, Kimball C. (November 2004). "Bacteria, Ulcers, and Ostracism?".  
  12. ^ "Barry J. Marshall – Biographical".  
  13. ^ Marshall BJ, Armstrong JA, McGechie DB, Glancy RJ (1985). "Attempt to fulfil Koch's postulates for pyloric Campylobacter". Med. J. Aust. 142 (8): 436–9.  
  14. ^ Van Der Weyden, Martin B; Armstrong, Ruth M; Gregory, Ann T (2005). "The 2005 Nobel Prize in Physiology or Medicine". Medical Journal of Australia 183 (11/12): 612–4. 
  15. ^ "Professor Barry Marshall". University of Western Australia. 28 July 2006. Archived from the original on 17 February 2007. Retrieved 28 January 2007. 
  16. ^ Marshall, Barry (26 August 2002). "Helicobacter pylori Research Laboratory".   Marshall's home page and various links can also be found there.
  17. ^ "Nobel laureate Marshall joins Penn State faculty". Penn State Live. 6 September 2007. Retrieved 6 September 2007. 
  18. ^ "The Nobel Prize in Physiology or Medicine 2005".  
  19. ^ "Curriculum Vitae".  
  20. ^ "It's an Honour".  
  21. ^ "Encaenia 2009".  


External links

  • Nobel Prize Inspiration Initiative
  • Marshall Nobel Prize lecture
  • Nobelprize.org bio
  • The Helicobacter Foundation Discussion Pages
  • The Helicobacter pylori Research Laboratory
  • The Helicobacter Foundation
  • Marshall's personal web page
  • Interview with Barry Marshall – Radio Live, May 2010.
  • Interview with Barry Marshall – BBC World Service 6, 7 and 8 November 2010, Interviewer: Owen Bennett-Jones, Programme series: The Interview. Marshall estimates that his discovery saves 500K lives a year. It rendered obsolete a multi-billion dollar drugs market aimed at treating stomach ulcers, as caused by "stress".


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